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Ichthyosis is a family of genetic skin diseases that can affect anybody and do not have any known cure as of now. Harlequin-type ichthyosis is a serious type of congenital ichthyosis and is characterized by thick layers of keratin on the fetal human skin. As the keratin becomes scaly it limits the movements of the growing child and also increases the risk of infection because of cracks in the skin.

Congenital Ichthyosis does not depend on race or ethnicity of parents but there is evidence that parents with a history of skin diseases and consanguineous parents are at a greater risk of conceiving a child afflicted by a form of congenital ichthyosis.

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